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Non-base-contacting residues enable kaleidoscopic evolution of metazoan C2H2 zinc finger DNA binding

Abstract Background The C2H2 zinc finger (C2H2-ZF) is the most numerous protein domain in many metazoans, but is not as frequent or diverse in other eukaryotes. The biochemical and evolutionary mechanisms that underlie the diversity of this DNA-binding domain exclusively in metazoans are, however, m...

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Huvudupphovsmän: Hamed S. Najafabadi, Michael Garton, Matthew T. Weirauch, Sanie Mnaimneh, Ally Yang, Philip M. Kim, Timothy R. Hughes
Materialtyp: Artigo
Språk:Inglês
Publicerad: BMC 2017-09-01
Serie:Genome Biology
Länkar:http://link.springer.com/article/10.1186/s13059-017-1287-y
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