Osmosensing, osmosignalling and inflammation: how intervertebral disc cells respond to altered osmolarity

Intervertebral disc (IVD) cells are naturally exposed to high osmolarity and complex mechanical loading, which drive microenvironmental osmotic changes. Age- and degeneration-induced degradation of the IVD’s extracellular matrix causes osmotic imbalance, which, together with an altered function of c...

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Bibliographic Details
Main Authors: A Sadowska, T Kameda, O Krupkova, K Wuertz-Kozak
Format: Artigo
Language:Inglês
Published: AO Research Institute Davos 2018-11-01
Series:European Cells & Materials
Subjects:
Intervertebral disc degeneration
degenerative disc disease
osmolarity
hyper-osmolarity
hypo-osmolarity
osmotic
inflammatory
transient receptor potential channel
aquaporin
tonicity-responsive enhancer binding protein.
Online Access:http://www.ecmjournal.org/papers/vol036/pdf/v036a17.pdf
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