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Influence of point mutations on the stability, dimerization and oligomerization of human cystatin C and its L68Q variant
Human cystatin C (hCC) is a small but very intriguing protein. Produced by all nucleated cells is found in almost all tissues and body fluids where, at physiological conditions, plays a role of a very potent inhibitor of cysteine proteases. Biologically active hCC is a monomeric protein but during c...
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Autori principali: | , , , , , |
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Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
Frontiers Media S.A.
2012-07-01
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Serie: | Frontiers in Molecular Neuroscience |
Soggetti: | |
Accesso online: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00082/full |
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