Proteolysis-targeting chimeras (PROTACs) in cancer therapy

Abstract Proteolysis-targeting chimeras (PROTACs) are engineered techniques for targeted protein degradation. A bifunctional PROTAC molecule with two covalently-linked ligands recruits target protein and E3 ubiquitin ligase together to trigger proteasomal degradation of target protein by the ubiquit...

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Autores principales: Xinyi Li, Wenchen Pu, Qingquan Zheng, Min Ai, Song Chen, Yong Peng
Formato: Artigo
Lenguaje:Inglês
Publicado: BMC 2022-04-01
Colección:Molecular Cancer
Materias:
PROTAC
Targeted cancer therapy
Ubiquitin-proteasome system
Protein degradation
Acceso en línea:https://doi.org/10.1186/s12943-021-01434-3
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