Atorvastatin promotes bone formation in aged apoE–/– mice through the Sirt1–Runx2 axis

Abstract Background Statins are the most widely used drugs in elderly patients; the most common clinical application of statins is in aged hyperlipemia patients. There are few studies on the effects and mechanisms of statins on bone in elderly mice with hyperlipemia. The study is to examine the effe...

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Bibliographic Details
Main Authors: Wei Hong, Zhanying Wei, Zhaohui Qiu, Zheng Li, Chensheng Fu, Zhibin Ye, Xiaoya Xu
Format: Artigo
Language:Inglês
Published: BMC 2020-08-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
ApoE−/− mice
Aged
Sirt1
Bone formation
Atorvastatin
Online Access:http://link.springer.com/article/10.1186/s13018-020-01841-0
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