Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells

Abstract Background Mesangial cell fibrosis, a typical symptom of diabetic nephropathy (DN), is a major contributor to glomerulosclerosis. We previously reported that the pharmacological blockade of lysophosphatidic acid (LPA) signaling improves DN. Although LPA signaling is implicated in diabetic r...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Donghee Kim, Ga-Young Nam, Eunhui Seo, Hee-Sook Jun
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-05-01
Colecção:Journal of Biomedical Science
Assuntos:
Diabetic nephropathy
Mesangial cells
Fibrosis
Lysophosphatidic acid
ChREBP
Smurf2
Acesso em linha:https://doi.org/10.1186/s12929-022-00814-1
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados