Kynurenine Promotes RANKL–Induced Osteoclastogenesis In Vitro by Activating the Aryl Hydrocarbon Receptor Pathway

There is increasing evidence of the involvement of the tryptophan metabolite kynurenine (KYN) in disrupting osteogenesis and contributing to aging-related bone loss. Here, we show that KYN has an effect on bone resorption by increasing osteoclastogenesis. We have previously reported that in vivo tre...

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Autori principali: Nada H. Eisa, Sakamuri V. Reddy, Ahmed M. Elmansi, Galina Kondrikova, Dmitry Kondrikov, Xing-Ming Shi, Chad M. Novince, Mark W. Hamrick, Meghan E. McGee-Lawrence, Carlos M. Isales, Sadanand Fulzele, William D. Hill
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2020-10-01
Serie:International Journal of Molecular Sciences
Soggetti:
Kynurenine
AhR
osteoclast
NFATc1
c-fos
Accesso online:https://www.mdpi.com/1422-0067/21/21/7931
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