The Molecular and Neuropathological Consequences of Genetic Risk for Alzheimer's Dementia

Alzheimer's dementia commonly impacts the health of older adults and lacks any preventative therapy. While Alzheimer's dementia risk has a substantial genetic component, the specific molecular mechanisms and neuropathologies triggered by most of the known genetic variants are unclear. Resu...

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Autori principali: Shinya Tasaki, Chris Gaiteri, Sara Mostafavi, Philip L. De Jager, David A. Bennett
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018-10-01
Serie:Frontiers in Neuroscience
Soggetti:
Alzheimer's disease
polygenic risk score
PheWAS
brain pathology
multi omics
epigenome
Accesso online:https://www.frontiersin.org/article/10.3389/fnins.2018.00699/full
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