A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles

α-Synuclein (αS) is a presynaptic protein whose aggregation is associated with Parkinson’s disease (PD). Although the physiological function of αS is still unclear, several lines of evidence indicate that this protein may play a role in the trafficking of synaptic vesicles (SVs) during neurotransmit...

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Bibliographic Details
Main Authors: Wing K. Man, Alfonso De Simone, Joseph D. Barritt, Michele Vendruscolo, Christopher M. Dobson, Giuliana Fusco
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Neuroscience
Subjects:
α-synuclein
synaptic vesicles
membrane interaction
cholesterol
nuclear magnetic resonance
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00018/full
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