TPP1 Enhances the Therapeutic Effects of Transplanted Aged Mesenchymal Stem Cells in Infarcted Hearts via the MRE11/AKT Pathway

BackgroundPoor cell survival after transplantation restricts the therapeutic potential of mesenchymal stem cell (MSC) transplantation into infarcted hearts, particularly in older individuals. TPP1, a component of the shelterin complex that is involved in telomere protection, is highly expressed in y...

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Detalhes bibliográficos
Main Authors: Kaixiang Yu, Zhiru Zeng, Si Cheng, Wangxing Hu, Chenyang Gao, Feng Liu, Jinyong Chen, Yi Qian, Dilin Xu, Jing Zhao, Xianbao Liu, Jian’an Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-10-01
Colecção:Frontiers in Cell and Developmental Biology
Assuntos:
stem cells therapy
myocardial infarction
aging
DNA repair
telomere
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcell.2020.588023/full
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