SRT1720 promotes survival of aged human mesenchymal stem cells via FAIM: a pharmacological strategy to improve stem cell-based therapy for rat myocardial infarction

SIRT1 has been proved to rejuvenate and improve the therapeutic efficacy of aged rat mesenchymal stem cells (MSCs). Herein, we investigate the protective effect of pretreatment with SIRT1 activator SRT1720 on aged human MSCs (hMSCs). The optimized pretreatment condition for aged hMSCs was determined...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Liu, Xianbao, Hu, Dexing, Zeng, Zhiru, Zhu, Wei, Zhang, Na, Yu, Hong, Chen, Han, Wang, Kan, Wang, Yingchao, Wang, Lengmei, Zhao, Jing, Zhang, Ling, Wu, Rongrong, Hu, Xinyang, Wang, Jian'an
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477573/
https://ncbi.nlm.nih.gov/pubmed/28383554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.107
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