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Extensive Changes in Transcriptomic “Fingerprints” and Immunological Cells in the Large Organs of Patients Dying of Acute Septic Shock and Multiple Organ Failure Caused by Neisseria meningitidis

Background: Patients developing meningococcal septic shock reveal levels of Neisseria meningitidis (106-108/mL) and endotoxin (101-103 EU/mL) in the circulation and organs, leading to acute cardiovascular, pulmonary and renal failure, coagulopathy and a high case fatality rate within 24 h.Objective:...

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Detalhes bibliográficos
Main Authors: Berit Sletbakk Brusletto, Else Marit Løberg, Bernt Christian Hellerud, Ingeborg Løstegaard Goverud, Jens Petter Berg, Ole Kristoffer Olstad, Unni Gopinathan, Petter Brandtzaeg, Reidun Øvstebø
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-02-01
Colecção:Frontiers in Cellular and Infection Microbiology
Assuntos:
IHC
MOF
Acesso em linha:https://www.frontiersin.org/article/10.3389/fcimb.2020.00042/full
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