A case of acute promyelocytic leukemia variant with derivative chromosome 3 der(3)t(3;8) associated with 8q partial gain

Abstract Background Acute promyelocytic leukemia (APL) is characterized by fusion of PML/RARα genes as a result of t(15;17)(q24;q21). APL is now one of the curable hematological malignancies thanks to molecularly targeted therapies based on all-trans retinoic acid (ATRA) and arsenic trioxide (ATX)....

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Main Authors: Filomena Nozza, Gabriella Vona, Stefania Trino, Fiorella D’Auria, Francesco La Rocca, Vitina Grieco, Luciana Possidente, Luciana De Luca, Pellegrino Musto
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-07-01
Colecção:Molecular Cytogenetics
Assuntos:
Acute promyelocytic leukemia
Molecular cytogenetics
c-myc gene
FISH
Painting
Chromosome 8
Acesso em linha:http://link.springer.com/article/10.1186/s13039-019-0445-1
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