Knockdown of miR-128a induces Lin28a expression and reverts myeloid differentiation blockage in acute myeloid leukemia

Lin28A is a highly conserved RNA-binding protein that concurs to control the balance between stemness and differentiation in several tissue lineages. Here, we report the role of miR-128a/Lin28A axis in blocking cell differentiation in acute myeloid leukemia (AML), a genetically heterogeneous disease...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: De Luca, Luciana, Trino, Stefania, Laurenzana, Ilaria, Tagliaferri, Daniela, Falco, Geppino, Grieco, Vitina, Bianchino, Gabriella, Nozza, Filomena, Campia, Valentina, D'Alessio, Francesca, La Rocca, Francesco, Caivano, Antonella, Villani, Oreste, Cilloni, Daniela, Musto, Pellegrino, Del Vecchio, Luigi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520910/
https://ncbi.nlm.nih.gov/pubmed/28569789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.253
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