Loss of DAP12 and FcRγ drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs.

Dap12 and FcRγ, the two transmembrane ITAM-containing signaling adaptors expressed in dendritic cells (DC), are implicated in the regulation of DC function. Several activating and adhesion receptors including integrins require these chains for their function in triggering downstream signaling and ef...

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Hlavní autoři: Grzegorz B Gmyrek, Holly M Akilesh, Daniel B Graham, Anja Fuchs, Lihua Yang, Mark J Miller, Gabriel J Sandoval, Kathleen C F Sheehan, Robert D Schreiber, Michael S Diamond, Wojciech Swat
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2013-01-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC3796521?pdf=render
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