Perfluorochemical‐facilitated plasminogen activator delivery to the airways: A novel treatment for inhalational smoke‐induced acute lung injury

Abstract Background Effective clinical management of airway clot and fibrinous cast formation of severe inhalational smoke‐induced acute lung injury (ISALI) is lacking. Aerosolized delivery of tissue plasminogen activator (tPA) is confounded by airway bleeding; single‐chain urokinase plasminogen act...

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Main Authors: Marla R. Wolfson, Perenlei Enkhbaatar, Satoshi Fukuda, Christina L. Nelson, Robert O. Williams III, Soraya Hengsawas Surasarang, Sawittree Sahakijpijarn, Gennaro Calendo, Andrey A. Komissarov, Galina Florova, Krishna Sarva, Steven I. Idell, Thomas H. Shaffer
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2020-03-01
Colecção:Clinical and Translational Medicine
Assuntos:
airway casts
inhalational acute lung injury
perfluorochemicals
plasminogen activators
Acesso em linha:https://doi.org/10.1002/ctm2.26
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