The exosome component Rrp6 is required for RNA polymerase II termination at specific targets of the Nrd1-Nab3 pathway.

The exosome and its nuclear specific subunit Rrp6 form a 3'-5' exonuclease complex that regulates diverse aspects of RNA biology including 3' end processing and degradation of a variety of noncoding RNAs (ncRNAs) and unstable transcripts. Known targets of the nuclear exosome include s...

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Autores principales: Melanie J Fox, Hongyu Gao, Whitney R Smith-Kinnaman, Yunlong Liu, Amber L Mosley
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2015-01-01
Colección:PLoS Genetics
Acceso en línea:http://europepmc.org/articles/PMC4378619?pdf=render
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