IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases

Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most prominent and evolutionarily conserved endoplasmic reticulum (ER) membrane protein. This transduces the signal of misfolded protein accumulation in the ER, named as ER stress, to the nucleus as “unfolded protein response...

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Hauptverfasser: Raghu Patil Junjappa, Prakash Patil, Kashi Raj Bhattarai, Hyung-Ryong Kim, Han-Jung Chae
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018-06-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
autoimmune diseases
cytokines
inflammation
IRE1α
regulated IRE1α-dependent decay
unfolded protein response signaling pathways
Online Zugang:https://www.frontiersin.org/article/10.3389/fimmu.2018.01289/full
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