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IRAK-2 regulates IL-1-mediated pathogenic Th17 cell development in helminthic infection.

Infection with the trematode parasite Schistosoma mansoni results in distinct heterogeneity of disease severity both in humans and in mice. In the experimental mouse model, severe disease is characterized by pronounced hepatic egg-induced granulomatous inflammation mediated by CD4 Th17 cells, wherea...

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Main Authors: Patrick M Smith, Berri Jacque, James R Conner, Alexander Poltorak, Miguel J Stadecker
格式: Artigo
語言:Inglês
出版: Public Library of Science (PLoS) 2011-10-01
叢編:PLoS Pathogens
在線閱讀:http://europepmc.org/articles/PMC3188523?pdf=render
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