Growth Plate Pathology in the Mucopolysaccharidosis Type VI Rat Model—An Experimental and Computational Approach

Background: Mucopolysaccharidoses (MPS) are a group of inherited metabolic diseases caused by impaired function or absence of lysosomal enzymes involved in degradation of glycosaminoglycans. Clinically, MPS are skeletal dysplasias, characterized by cartilage abnormalities and disturbances in the pro...

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Bibliographische Detailangaben
Hauptverfasser: Johana M. Guevara-Morales, Michael Frohbergh, Hector Castro-Abril, Juan J. Vaca-González, Luis A. Barrera, Diego A. Garzón-Alvarado, Edward Schuchman, Calogera Simonaro
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-05-01
Schriftenreihe:Diagnostics
Schlagworte:
mucopolysaccharidosis type VI
growth plate histology
columnar arrangement
skeletal dysplasia
growth plate computational model
Online Zugang:https://www.mdpi.com/2075-4418/10/6/360
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