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Role of p53 in Cell Death and Human Cancers

p53 is a nuclear transcription factor with a pro-apoptotic function. Since over 50% of human cancers carry loss of function mutations in p53 gene, p53 has been considered to be one of the classical type tumor suppressors. Mutant p53 acts as the dominant-negative inhibitor toward wild-type p53. Indee...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Toshinori Ozaki, Akira Nakagawara
Format: Artigo
Langue:Inglês
Publié: MDPI AG 2011-03-01
Collection:Cancers
Sujets:
p53
Accès en ligne:http://www.mdpi.com/2072-6694/3/1/994/
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