Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells

Chalcones are valuable structures for drug discovery due to their broad bioactivity spectrum. In this study, we evaluated 20 synthetic chalcones against estrogen-receptor-positive breast cancer cells (MCF-7 line) and triple-negative breast cancer (TNBC) cells (MDA-MB-231 line). Antiproliferative scr...

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Detalhes bibliográficos
Main Authors: Mariana Bastos dos Santos, Daiane Bertholin Anselmo, Jéssica Gisleine de Oliveira, Bruna V. Jardim-Perassi, Diego Alves Monteiro, Gabriel Silva, Eleni Gomes, Ana Lucia Fachin, Mozart Marins, Débora Aparecida Pires de Campos Zuccari, Luis Octavio Regasini
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2019-01-01
Colecção:Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:
chalcones
cancer
p53
antiproliferative
apoptosis
Acesso em linha:http://dx.doi.org/10.1080/14756366.2019.1615485
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