Rotor termination is critically dependent on kinetic properties of I kur inhibitors in an in silico model of chronic atrial fibrillation.

Inhibition of the atrial ultra-rapid delayed rectifier potassium current (I Kur) represents a promising therapeutic strategy in the therapy of atrial fibrillation. However, experimental and clinical data on the antiarrhythmic efficacy remain controversial. We tested the hypothesis that antiarrhythmi...

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Hlavní autoři: Eberhard P Scholz, Paola Carrillo-Bustamante, Fathima Fischer, Mathias Wilhelms, Edgar Zitron, Olaf Dössel, Hugo A Katus, Gunnar Seemann
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2013-01-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC3869770?pdf=render
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