Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus.

H3K9 trimethylation (H3K9me3) and binding of PcG repressor complex-1 (PRC1) may play crucial roles in the epigenetic silencing of the p16 gene. However, the mechanism of the initiation of this trimethylation is unknown.In the present study, we found that upregulating the expression of PRC1 component...

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Detaylı Bibliyografya
Asıl Yazarlar: Qiang Li, Xiuhong Wang, Zheming Lu, Baozhen Zhang, Zhenpo Guan, Zhaojun Liu, Qiming Zhong, Liankun Gu, Jing Zhou, Budong Zhu, Jiafu Ji, Dajun Deng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science (PLoS) 2010-10-01
Seri Bilgileri:PLoS ONE
Online Erişim:http://europepmc.org/articles/PMC2966406?pdf=render
Etiketler: Etiketle
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