Polycomb CBX7 Directly Controls Trimethylation of Histone H3 at Lysine 9 at the p16 Locus

BACKGROUND: H3K9 trimethylation (H3K9me3) and binding of PcG repressor complex-1 (PRC1) may play crucial roles in the epigenetic silencing of the p16 gene. However, the mechanism of the initiation of this trimethylation is unknown. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we found that...

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Detalhes bibliográficos
Main Authors: Li, Qiang, Wang, Xiuhong, Lu, Zheming, Zhang, Baozhen, Guan, Zhenpo, Liu, Zhaojun, Zhong, Qiming, Gu, Liankun, Zhou, Jing, Zhu, Budong, Ji, Jiafu, Deng, Dajun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966406/
https://ncbi.nlm.nih.gov/pubmed/21060834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013732
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