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Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus.
H3K9 trimethylation (H3K9me3) and binding of PcG repressor complex-1 (PRC1) may play crucial roles in the epigenetic silencing of the p16 gene. However, the mechanism of the initiation of this trimethylation is unknown.In the present study, we found that upregulating the expression of PRC1 component...
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| Hlavní autoři: | , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science (PLoS)
2010-10-01
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| Edice: | PLoS ONE |
| On-line přístup: | http://europepmc.org/articles/PMC2966406?pdf=render |
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