Lipocalin-2 Functions as Inhibitor of Innate Resistance to Mycobacterium tuberculosis

Lipocalin-2 is a constituent of the neutrophil secondary granules and is expressed de novo by macrophages and epithelium in response to inflammation. Lipocalin-2 acts in a bacteriostatic fashion by binding iron-loaded siderophores required for bacterial growth. Mycobacterium tuberculosis (M.tb) prod...

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Main Authors: Sara Louise Dahl, Joshua S. Woodworth, Christian Johann Lerche, Elisabeth Præstekjær Cramer, Pia Rude Nielsen, Claus Moser, Allan Randrup Thomsen, Niels Borregaard, Jack Bernard Cowland
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-11-01
Serier:Frontiers in Immunology
Fag:
Mycobacterium tuberculosis
NGAL
24p3
iron metabolism
innate immunity
neutrophils
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2018.02717/full
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