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Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

Summary: Loss of heterozygosity (LOH) of the adenomatous polyposis coli (APC) gene triggers a series of molecular events leading to intestinal adenomagenesis. Haploinsufficiency of the cohesin Rad21 influences multiple initiating events in colorectal cancer (CRC). We identify Rad21 as a gatekeeper o...

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Библиографические подробности
Главные авторы: Huiling Xu, Yuqian Yan, Siddhartha Deb, Danny Rangasamy, Markus Germann, Jordane Malaterre, Noreen C. Eder, Robyn L. Ward, Nicholas J. Hawkins, Richard W. Tothill, Long Chen, Neil J. Mortensen, Stephen B. Fox, Michael J. McKay, Robert G. Ramsay
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2014-12-01
Серии:Cell Reports
Online-ссылка:http://www.sciencedirect.com/science/article/pii/S2211124714009280
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