Cationic Amphipathic Antimicrobial Peptides Perturb the Inner Membrane of Germinated Spores Thus Inhibiting Their Outgrowth

The mode of action of four cationic amphipathic antimicrobial peptides (AMPs) was evaluated against the non-pathogenic, Gram-positive, spore-forming bacterium, Bacillus subtilis. The AMPs were TC19, TC84, BP2, and the lantibiotic Nisin A. TC19 and TC84 were derived from the human thrombocidin-1. Bac...

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Main Authors: Soraya Omardien, Jan Wouter Drijfhout, Sebastian A. Zaat, Stanley Brul
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-09-01
Colecção:Frontiers in Microbiology
Assuntos:
antimicrobial peptides
thrombocidin
bactericidal permeability increasing protein
lantibiotics
Bacillus subtilis spores
inner membrane damage
Acesso em linha:https://www.frontiersin.org/article/10.3389/fmicb.2018.02277/full
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