Claudin-12 is not required for blood–brain barrier tight junction function

Abstract Background The blood–brain barrier (BBB) ensures central nervous system (CNS) homeostasis by strictly controlling the passage of molecules and solutes from the bloodstream into the CNS. Complex and continuous tight junctions (TJs) between brain endothelial cells block uncontrolled paracellu...

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Main Authors: Mariana Castro Dias, Caroline Coisne, Pascale Baden, Gaby Enzmann, Lillian Garrett, Lore Becker, Sabine M. Hölter, German Mouse Clinic Consortium, Martin Hrabě de Angelis, Urban Deutsch, Britta Engelhardt
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-09-01
Serier:Fluids and Barriers of the CNS
Fag:
Claudin-12
Tight junctions
Blood–brain barrier
Experimental autoimmune encephalomyelitis
Online adgang:http://link.springer.com/article/10.1186/s12987-019-0150-9
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