Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria

Recent studies on the respiratory chain of Ascaris suum showed that the mitochondrial NADH-fumarate reductase system composed of complex I, rhodoquinone and complex II plays an important role in the anaerobic energy metabolism of adult A. suum. The system is the major pathway of energy metabolism f...

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Main Authors: Daniel Ken Inaoka, Tomoo Shiba, Dan Sato, Emmanuel Oluwadare Balogun, Tsuyoshi Sasaki, Madoka Nagahama, Masatsugu Oda, Shigeru Matsuoka, Junko Ohmori, Teruki Honma, Masayuki Inoue, Kiyoshi Kita, Shigeharu Harada
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2015-07-01
Colecção:International Journal of Molecular Sciences
Assuntos:
complex II
NADH-fumarate reductase system
fumarate respiration
Ascaris suum
mitochondria
flutolanil
crystal structure
structure-based drug design
antiparasitic agent
Acesso em linha:http://www.mdpi.com/1422-0067/16/7/15287
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