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A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway
Abstract Background Long noncoding RNAs (lncRNAs) are recently found to be critical regulators of the epigenome. However, our knowledge of their role in osteoarthritis (OA) development is limited. This study investigates the mechanism by which HOTAIR, a key lncRNA with elevated expression in OA, aff...
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主要な著者: | , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
BMC
2020-07-01
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シリーズ: | BMC Molecular and Cell Biology |
主題: | |
オンライン・アクセス: | http://link.springer.com/article/10.1186/s12860-020-00299-6 |
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