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A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway

Abstract Background Long noncoding RNAs (lncRNAs) are recently found to be critical regulators of the epigenome. However, our knowledge of their role in osteoarthritis (OA) development is limited. This study investigates the mechanism by which HOTAIR, a key lncRNA with elevated expression in OA, aff...

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書誌詳細
主要な著者: Yang Yang, Dan Xing, Yawei Wang, Haobo Jia, Bing Li, Jiao Jiao Li
フォーマット: Artigo
言語:Inglês
出版事項: BMC 2020-07-01
シリーズ:BMC Molecular and Cell Biology
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オンライン・アクセス:http://link.springer.com/article/10.1186/s12860-020-00299-6
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