A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway

BACKGROUND: Long noncoding RNAs (lncRNAs) are recently found to be critical regulators of the epigenome. However, our knowledge of their role in osteoarthritis (OA) development is limited. This study investigates the mechanism by which HOTAIR, a key lncRNA with elevated expression in OA, affects OA...

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Vydáno v:BMC Mol Cell Biol
Hlavní autoři: Yang, Yang, Xing, Dan, Wang, Yawei, Jia, Haobo, Li, Bing, Li, Jiao Jiao
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350747/
https://ncbi.nlm.nih.gov/pubmed/32650720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-020-00299-6
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