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A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway

BACKGROUND: Long noncoding RNAs (lncRNAs) are recently found to be critical regulators of the epigenome. However, our knowledge of their role in osteoarthritis (OA) development is limited. This study investigates the mechanism by which HOTAIR, a key lncRNA with elevated expression in OA, affects OA...

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Bibliografske podrobnosti
izdano v:BMC Mol Cell Biol
Main Authors: Yang, Yang, Xing, Dan, Wang, Yawei, Jia, Haobo, Li, Bing, Li, Jiao Jiao
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350747/
https://ncbi.nlm.nih.gov/pubmed/32650720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-020-00299-6
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