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A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway

BACKGROUND: Long noncoding RNAs (lncRNAs) are recently found to be critical regulators of the epigenome. However, our knowledge of their role in osteoarthritis (OA) development is limited. This study investigates the mechanism by which HOTAIR, a key lncRNA with elevated expression in OA, affects OA...

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Pubblicato in:BMC Mol Cell Biol
Autori principali: Yang, Yang, Xing, Dan, Wang, Yawei, Jia, Haobo, Li, Bing, Li, Jiao Jiao
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350747/
https://ncbi.nlm.nih.gov/pubmed/32650720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-020-00299-6
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