A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway

Abstract Background Long noncoding RNAs (lncRNAs) are recently found to be critical regulators of the epigenome. However, our knowledge of their role in osteoarthritis (OA) development is limited. This study investigates the mechanism by which HOTAIR, a key lncRNA with elevated expression in OA, aff...

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Hlavní autoři: Yang Yang, Dan Xing, Yawei Wang, Haobo Jia, Bing Li, Jiao Jiao Li
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2020-07-01
Edice:BMC Molecular and Cell Biology
Témata:
Osteoarthritis
Chondrocytes
Long noncoding RNA
HOTAIR
WIF-1
Wnt/β-catenin pathway
On-line přístup:http://link.springer.com/article/10.1186/s12860-020-00299-6
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