Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast.

To better understand off-target effects of widely prescribed psychoactive drugs, we performed a comprehensive series of chemogenomic screens using the budding yeast Saccharomyces cerevisiae as a model system. Because the known human targets of these drugs do not exist in yeast, we could employ the y...

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Bibliographic Details
Main Authors: Elke Ericson, Marinella Gebbia, Lawrence E Heisler, Jan Wildenhain, Mike Tyers, Guri Giaever, Corey Nislow
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2008-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2483942?pdf=render
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