Dabigatran Suppresses PAR-1/SphK/S1P Activation of Astrocytes in Experimental Autoimmune Encephalomyelitis Model

Multiple sclerosis (MS) is an inflammatory autoimmune disease affecting the central nervous system (CNS) that currently does not have any effective treatment. Experimental autoimmune encephalomyelitis (EAE) is often employed as a model to mimic the clinical manifestations of MS, mainly CNS demyelina...

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Detalhes bibliográficos
Main Authors: Rong Chen, Xing Cao, Wenxiu Luo, Haodi Yang, Xinya Luo, Juming Yu, Jiaming Luo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-06-01
Colecção:Frontiers in Molecular Neuroscience
Assuntos:
multiple sclerosis
experimental autoimmune encephalomyelitis
dabigatran
protease-activated receptors
sphingosine-1-phosphate
coagulation
Acesso em linha:https://www.frontiersin.org/article/10.3389/fnmol.2020.00114/full
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