Signaling in fibrosis: TGF-β, WNT, and YAP/TAZ converge

Chronic organ injury leads to fibrosis and eventually organ failure. Fibrosis is characterized by excessive synthesis, remodeling and contraction of extracellular matrix produced by myofibroblasts. Myofibroblasts are the key cells in the pathophysiology of fibrotic disorders and their differentiatio...

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Detaylı Bibliyografya
Asıl Yazarlar: Bram ePiersma, Ruud A Bank, Miriam eBoersema
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2015-09-01
Seri Bilgileri:Frontiers in Medicine
Konular:
Fibrosis
Wnt
Hippo
myofibroblast
signal integration
TGF-β
Online Erişim:http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00059/full
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