Signaling in fibrosis: TGF-β, WNT, and YAP/TAZ converge

Chronic organ injury leads to fibrosis and eventually organ failure. Fibrosis is characterized by excessive synthesis, remodeling and contraction of extracellular matrix produced by myofibroblasts. Myofibroblasts are the key cells in the pathophysiology of fibrotic disorders and their differentiatio...

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Bibliografische gegevens
Hoofdauteurs: Bram ePiersma, Ruud A Bank, Miriam eBoersema
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2015-09-01
Reeks:Frontiers in Medicine
Onderwerpen:
Fibrosis
Wnt
Hippo
myofibroblast
signal integration
TGF-β
Online toegang:http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00059/full
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