Phosphorus containing analogues of SAHA as inhibitors of HDACs

Histone deacetylases (HDACs) are a family of enzymes responsible for regulating DNA transcription by modulating its binding to histone proteins. HDACs are overexpressed in several types of cancers and are recognised as drug targets. Vorinostat, or suberanilohydroxamic acid (SAHA), is an histone deac...

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Главные авторы: Michael D. Pun, Hsin-Hua Wu, Feyisola P. Olatunji, Britany N. Kesic, John W. Peters, Clifford E. Berkman
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis Group 2022-12-01
Серии:Journal of Enzyme Inhibition and Medicinal Chemistry
Предметы:
HDAC
phosphate
phosphoramidate
phosphorothiolate
SAHA
Online-ссылка:https://www.tandfonline.com/doi/10.1080/14756366.2022.2063281
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