Phosphorus containing analogues of SAHA as inhibitors of HDACs

Histone deacetylases (HDACs) are a family of enzymes responsible for regulating DNA transcription by modulating its binding to histone proteins. HDACs are overexpressed in several types of cancers and are recognised as drug targets. Vorinostat, or suberanilohydroxamic acid (SAHA), is an histone deac...

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Detalhes bibliográficos
Principais autores: Michael D. Pun, Hsin-Hua Wu, Feyisola P. Olatunji, Britany N. Kesic, John W. Peters, Clifford E. Berkman
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2022-12-01
coleção:Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:
HDAC
phosphate
phosphoramidate
phosphorothiolate
SAHA
Acesso em linha:https://www.tandfonline.com/doi/10.1080/14756366.2022.2063281
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