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A click-ready pH-triggered phosphoramidate-based linker for controlled release of monomethyl auristatin E
In this work, we developed a novel “click”-ready pH-cleavable phosphoramidate linker for controlled-release of monomethyl auristantin E (MMAE) in antibody- and small molecule-drug conjugates application. This water-soluble linker was found to have tremendous stability at physiological pHs while rapi...
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| Publicado no: | Tetrahedron Lett |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7665082/ https://ncbi.nlm.nih.gov/pubmed/33191958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2020.152398 |
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