Phosphorus containing analogues of SAHA as inhibitors of HDACs

Histone deacetylases (HDACs) are a family of enzymes responsible for regulating DNA transcription by modulating its binding to histone proteins. HDACs are overexpressed in several types of cancers and are recognised as drug targets. Vorinostat, or suberanilohydroxamic acid (SAHA), is an histone deac...

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Autori principali: Michael D. Pun, Hsin-Hua Wu, Feyisola P. Olatunji, Britany N. Kesic, John W. Peters, Clifford E. Berkman
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2022-12-01
Serie:Journal of Enzyme Inhibition and Medicinal Chemistry
Soggetti:
HDAC
phosphate
phosphoramidate
phosphorothiolate
SAHA
Accesso online:https://www.tandfonline.com/doi/10.1080/14756366.2022.2063281
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