Phosphorus containing analogues of SAHA as inhibitors of HDACs

Histone deacetylases (HDACs) are a family of enzymes responsible for regulating DNA transcription by modulating its binding to histone proteins. HDACs are overexpressed in several types of cancers and are recognised as drug targets. Vorinostat, or suberanilohydroxamic acid (SAHA), is an histone deac...

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Bibliografski detalji
Glavni autori: Michael D. Pun, Hsin-Hua Wu, Feyisola P. Olatunji, Britany N. Kesic, John W. Peters, Clifford E. Berkman
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis Group 2022-12-01
Serija:Journal of Enzyme Inhibition and Medicinal Chemistry
Teme:
HDAC
phosphate
phosphoramidate
phosphorothiolate
SAHA
Online pristup:https://www.tandfonline.com/doi/10.1080/14756366.2022.2063281
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