Phosphorus containing analogues of SAHA as inhibitors of HDACs

Histone deacetylases (HDACs) are a family of enzymes responsible for regulating DNA transcription by modulating its binding to histone proteins. HDACs are overexpressed in several types of cancers and are recognised as drug targets. Vorinostat, or suberanilohydroxamic acid (SAHA), is an histone deac...

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Bibliografische gegevens
Hoofdauteurs: Michael D. Pun, Hsin-Hua Wu, Feyisola P. Olatunji, Britany N. Kesic, John W. Peters, Clifford E. Berkman
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis Group 2022-12-01
Reeks:Journal of Enzyme Inhibition and Medicinal Chemistry
Onderwerpen:
HDAC
phosphate
phosphoramidate
phosphorothiolate
SAHA
Online toegang:https://www.tandfonline.com/doi/10.1080/14756366.2022.2063281
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