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Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR
Abstract Background In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates from degradation of redundant self-components. Whether and how AAR and a...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BMC
2019-05-01
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| シリーズ: | Cell Communication and Signaling |
| 主題: | |
| オンライン･アクセス: | http://link.springer.com/article/10.1186/s12964-019-0354-2 |
| タグ: |
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