The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis

Estrogens, in particular 17β-estradiol (E2), have a strong influence on the immune system and also affect pathological conditions such as autoimmune diseases. The biological effects of E2 are mediated by two intracellular receptors, i.e., estrogen receptor (ER)α and ERβ, which function as ligand-act...

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Bibliographic Details
Main Authors: Maria Luisa Dupuis, Fabrizio Conti, Angela Maselli, Maria Teresa Pagano, Anna Ruggieri, Simona Anticoli, Alessandra Fragale, Lucia Gabriele, Maria Cristina Gagliardi, Massimo Sanchez, Fulvia Ceccarelli, Cristiano Alessandri, Guido Valesini, Elena Ortona, Marina Pierdominici
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
estrogen receptor β
silibinin
T lymphocytes
immunity
sex
rheumatoid arthritis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01903/full
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