The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis

Estrogens, in particular 17β-estradiol (E2), have a strong influence on the immune system and also affect pathological conditions such as autoimmune diseases. The biological effects of E2 are mediated by two intracellular receptors, i.e., estrogen receptor (ER)α and ERβ, which function as ligand-act...

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Detalhes bibliográficos
Main Authors: Maria Luisa Dupuis, Fabrizio Conti, Angela Maselli, Maria Teresa Pagano, Anna Ruggieri, Simona Anticoli, Alessandra Fragale, Lucia Gabriele, Maria Cristina Gagliardi, Massimo Sanchez, Fulvia Ceccarelli, Cristiano Alessandri, Guido Valesini, Elena Ortona, Marina Pierdominici
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-08-01
Colecção:Frontiers in Immunology
Assuntos:
estrogen receptor β
silibinin
T lymphocytes
immunity
sex
rheumatoid arthritis
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2018.01903/full
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