Do changes in DNA methylation mediate or interact with SNP variation? A pharmacoepigenetic analysis

Abstract Background In studies with multi-omics data available, there is an opportunity to investigate interdependent mechanisms of biological causality. The GAW20 data set includes both DNA genotype and methylation measures before and after fenofibrate treatment. Using change in triglyceride (TG) l...

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Autori principali: Virginia A. Fisher, Lan Wang, Xuan Deng, Chloé Sarnowski, L. Adrienne Cupples, Ching-Ti Liu
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2018-09-01
Serie:BMC Genetics
Soggetti:
Causal modeling
Genomic data integration
Gene-methylation interaction
Indirect effects
Triglycerides
Genofibrate treatment
Accesso online:http://link.springer.com/article/10.1186/s12863-018-0635-6
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