Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway

Specnuezhenide (SPN), one of the main ingredients of Chinese medicine “Nü-zhen-zi”, has anti-angiogenic and vision improvement effects. However, studies of its effect on retinal neovascularization are limited so far. In the present study, we established a vascular endothelial growth factor A (VEGFA)...

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Detalhes bibliográficos
Main Authors: Jianming Wu, Xiao Ke, Wei Fu, Xiaoping Gao, Hongcheng Zhang, Wei Wang, Na Ma, Manxi Zhao, Xiaofeng Hao, Zhirong Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2016-12-01
Colecção:Molecules
Assuntos:
specnuezhenide
angiogenesis
hypoxia-inducible factor-1
oxygen-induced retinopathy
vascular endothelial growth factor
Acesso em linha:http://www.mdpi.com/1420-3049/21/12/1756
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